Fox squirrels are a relatively new animal model in finding a cure for Gunther’s disease. Already, findings have led to experimental bone marrow transplants which were successful in a few cases. Additionally, blood transfusions to suppress heme production as well as spleen removal have helped some patients. Realistically, a cure for Gunther’s disease is still many years off. For now, patients can hope that the fox squirrel will soon share its secret for beating the symptoms of Gunther’s disease.
The zebrafish model is crucial to gene discovery, allowing scientists to uncover important clues about the function of candidate genes. Because they reproduce rapidly and have very high reproduction rates, researchers have access to multiple generations and a large number of fish. Additionally, exceptional tools exist for genetic manipulation of zebrafish, making them ideal for developing gene therapies and holds much hope for future CHD research.
Researchers at Washington State University are studying grizzly bears raised in captivity to figure out how the bears’ hearts undergo such dramatic and helpful changes during hibernation. Understanding how the physical and chemical changes occur that allow grizzly bears to avoid blood clots and ruptured arteries could lead to breakthroughs in long awaited treatment for human heart disease.
For many years, the actual cause of Hashimoto’s Thyroiditis was highly disputed. There is strong evidence to support the theory that individuals who develop HT are often genetically predisposed to it. When obese and regular chickens were bred, several offspring inherited spontaneous autoimmune thyroiditis- leading to the conclusion that specific thyroid genes combined with specific immune regulatory genes are responsible for susceptibility to HT.
Tay-Sachs disease is a genetic disorder caused by the absence of the vital protein Hexosaminidase A isoenzyme. Hex-A breaks down fatty substances called GM2 gangliosides. However, infants with Tay-Sachs possess a gene mutation that makes them unable to produce Hex-A. As a result, fatty substances, or lipids, quickly accumulate inside neurons causing severe nerve damage. The rapid deterioration of the nervous system poses a challenge to researchers, however the answer could lie with an animal that has been around since biblical times- the Jacob sheep.
Narcolepsy is a neurological disorder caused by the brain’s inability to regulate sleep-wake cycles. Working with narcoleptic Doberman Pinschers, researchers discovered that canine narcolepsy is inherited directly from the parents and is an autosomal recessive trait, meaning both parents must pass down the mutated gene for the offspring to develop the disorder. Although there is not yet a cure for human narcolepsy the Doberman Pinscher may provide an important clue to understanding why they both fell asleep…on and off the job.
Jet lag is caused by the body’s inability to adjust its circadian rhythm to a new time zone. Much of our understanding of jet lag has come from research on the degu, a small rodent that neither flies nor experiences jet lag. This remarkable rodent can reset its circadian rhythm very easily. Orally administered doses of the sleep hormone melatonin have aided the degu in readjusting its sleep schedule, which makes this a possible treatment for humans as well.
Every four in 10,000 people in the United States have dilated cardiomyopathy, a disease that causes the left ventricle of the heart to become enlarged. Turkey hearts can serve as a model for the human heart as it undergoes heart failure and cardiomyopathy because their hearts are very similar. By countering a mutated form of cardiac muscle protein with another form of mutated protein, a heart’s normal condition can be restored.
Malaria is caused by an organism that shifts its shape a lot, so a vaccine is very hard to develop. Malarial merozoite surface proteins, or MSPs, were identified as a viable vaccine for malaria. To mass-produce MSPs, scientists genetically engineered a herd of goats to produce MSPs in their milk. Last year, more goats that produced milk with vaccine were bred in Houston—their purpose is to produce an economic drinkable form of malaria vaccine for third world countries.
Alzheimer's Disease (AD) is a form of dementia that results in memory loss and the decline in other cognitive functions. Scientists have recently discovered nanobodies in camels that can possibly serve as transporters to deliver medicine directly to the brains of patients suffering with Alzheimer's.