From Chinchillas to Humans: Decoding Hearing Loss

Hearing is a complicated process. To help decode how we hear and the issues that can occur within the ear, researchers have been studying chinchillas for over 50 years.

Chinchillas hear similarly to the way in which humans do, making them great models for researchers to use. For instance, these furry animals have similarly-sized ear structures and their hearing range is fairly close to that of humans. Chinchillas can also be trained with auditory stimuli that are relevant to humans and they have a calm nature that allows scientists to take measurements on them from all levels of their auditory systems.

Similarly to humans, chinchillas can suffer from several types of hearing impairment. Typically, their hearing loss falls into one of three categories: conductive hearing loss, sensorineural hearing loss or mixed hearing loss.

Conductive hearing loss occurs in the middle or outer ear when sound waves are not able to travel to the inner ear. This happens when the ear canal is blocked with wax or due to bone abnormalities. For instance, there are diseases like superior canal dehiscence in which there are natural breaks in the bony covering in the semicircular canals of the inner ear. This causes some of the sound to get to the cochlea (an inner ear structure that serves as the ear’s main sensor) but “leak” out.

One researcher studying these topics is Dr. John Rosowski, a comparative physiologist and Co-Director of the Wallace Middle-Ear Research Unit at Mass. Eye and Ear. He studies the relationship between the structure and function of the middle and external ear. According to his research, introducing holes into the bony inner ear causes dramatic changes in the hearing of chinchillas. As a result, the amount of sound delivered to the inner ear decreases, preventing this sound from traveling to the brain via the auditory nerve.

Chinchillas were the first animals to be tested for superior canal dehiscence and research on them has helped scientists learn how to treat the disease in humans. For instance, surgical procedures now exist that allow doctors to fix breaks in the inner ear bone.

Furthermore, while conductive hearing loss occurs in the middle and outer ear, sensorineural hearing loss takes place when the inner ear or auditory nerve is damaged. One of the most common types of this hearing loss is noise-induced hearing loss (NIHL), which is caused by excessive exposure to loud noises, especially to sounds over 80 decibels (dB).

Loud noise can damage the cochlea by overworking the hair cells in it that transmit auditory information. This causes them to splay, which breaks the linkages between them, rendering them unable to transmit sensory information. Since mammals cannot regenerate these hair cells, this damage is irreversible.

Similarly, loud noise can also damage the auditory nerve, but this damage is harder to spot because it doesn’t affect hearing test results. Instead, it makes it difficult for a person to understand and distinguish between sounds in loud environments.

Currently, there are no medical treatments available to fix hearing loss related to damage in the inner ear, like noise-induced hearing loss, a permanent condition that can only be countered with devices like cochlear implants. This technology consists of external sound receivers and small microchip computers and it directly stimulates the auditory nerve in the inner ear. While this gives those with hearing loss in the inner ear the general ability to hear sound, it does not necessarily help them to distinguish between individual noises.

However, even these implants have their limitations. As Dr. Rosowski notes, cochlear implants are only useful if hair cells are absent but there is a way to get sound information back to the nerves. “If you don’t have any nerves,” he says, “then the cochlear implant will do nothing for you.”

The final type of hearing loss is mixed hearing loss, which is a combination of both conductive and sensorineural hearing loss. It often occurs when an inner ear or auditory nerve defect already exists and conductive hearing loss develops over it.

Chinchillas have also helped researchers understand more about the two main paths through which sound reaches the inner ear: air conduction and bone conduction. Air conduction occurs when sound waves move through the air near and in the ear canal, while bone conduction occurs through vibrations transferred by bones in the skull.

Under normal circumstances, air conduction is the more important method. This is how most of our hearing occurs, and it is three orders of magnitude higher in sensitivity than bone conduction. However, Dr. Rosowski says that, “if you were to lose air conduction sensitivity, some of your hearing then would be through bone conduction.”

Bone conduction is also useful in clinics, where doctors use bone conduction headphones to bypass the middle ear to determine the health of the inner ear. This is particularly useful in cases of mixed hearing loss when it is unclear whether the issue is more in the inner or middle ear. In this case, sensors are placed on the back of the ear, and bone vibrations are analyzed to determine problem areas in the ear.

Similarly to bone versus air conduction, outer/middle and inner ear hearing loss have different levels of severity. Inner ear hearing loss is typically more difficult to deal with than middle or outer hearing loss. This is because it cannot be helped as easily. Since the outer and middle ear have no way to distinguish between sounds, the inner ear is crucial in sound distinction. The middle ear is essentially an amplifier, while the inner ear acts as an interpreter.

However, Dr. Rosowski notes, conductive hearing loss can still be very extreme. He explains the importance of the smallest bones in the human body, three bones in the middle ear called the hammer (malleus), the anvil (incus) and the stirrup (stapes) that are together known as the ossicular chain. He notes, “If there is a break in the ossicular chain, even if everything else is normal, you can have very severe hearing loss and become almost entirely dependent on bone conduction.”

To learn more about the middle ear, researchers, including Dr. Rosowski, have created a device that uses optical coherence vibrography (an imaging tool that allows researchers to visualize tiny movements of part of the body like the ear) to help visualize how sound-induced vibrations travel in the ear. Historically, surgery has been needed to observe the middle ear, but this device has allowed for the simultaneous measurement of the structure and motion at over 10,000 points on the bone surface and eardrum of chinchillas’ ears. This is a huge improvement from the 30 points that have been measured in previous sound vibration studies as it gives a much clearer picture of what is actually going on in the ear.

For now, this device has only been used on chinchillas, but scientists are planning to study human cadaver ears to find out if the observations made in chinchillas also occur in humans. If so, this could be a major breakthrough in the future of technology for hearing loss diagnosis and treatment and hopefully, more people would be able to get the help they need.

  • To help decode how we hear and the issues that can occur within the ear, researchers have been studying chinchillas for several decades. 
  • Chinchillas hear similarly to the way in which humans do, making them great models for research. 
  • Chinchillas have specifically helped researchers understand more about the two main paths through which sound reaches the inner ear: air conduction and bone conduction. 


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Henry, Kenneth S., et al. “Divergent Auditory Nerve Encoding Deficits Between Two Common Etiologies of Sensorineural Hearing Loss.” The Journal of Neuroscience, 28 August 2019,

Hirvonen, Timo P., et al. “Superior Canal Dehiscence: Mechanisms of Pressure Sensitivity in a Chinchilla Model.” JAMA Network, November 2001,

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Editorial Team

  • Chief Editor: Karishma Goswami
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Sybil Walker Barnes, CAE, is Director of Communications at the Federation of American Societies for Experimental Biology in Bethesda, MD.  She holds a Bachelor of Arts degree from Howard University in Washington, D.C., with a major in Journalism. She also earned the Certified Association Executive designation from the American Society of Association Executives. 

Content Expert

John J. Rosowski, Ph.D., is a Professor of Health Sciences and Technology at Harvard Medical School and the Co-Director of the Wallace Middle-Ear Research Unit of Massachusetts Eye and Ear. He studies the relationship between the structure and function of the middle and external ear and is working towards improving the diagnosis and treatment of conductive hearing loss. 

About the Author

Spencer Lyudovyk

Spencer is a junior at High Technology High School in New Jersey. This year, he is a writer and social media team manager for Curious Science Writers. He joined the cSw program because he believes it is crucial to educate the general public about different scientific topics, especially those relevant to their lives. He wishes to help make such information accessible for anyone who is interested as it could help people make informed decisions and prevent misinformation from spreading. Besides science communication, Spencer enjoys reading, playing guitar, programming and participating in politics.