Basset Hounds may replace the Arabian horse model for SCID research in children. The main reason is that the Hounds have the gene defect that’s most commonly involved with SCID in children. Simply put, the defect matches up, and this is important when considering potential animal models. Besides the fact that Hounds are genetically similar to children in terms of the gene that expresses SCID, they also cost less to feed, have shorter gestation periods, and produce more offspring per year than Arabian horses.
Most children will experience at least one episode of otitis media, or a middle ear infection, by the time they reach age three, making it one of the most common pediatric infections in the world. For years, rats, mice, and even monkeys gave researchers some insight into how this infection behaved within animal models; however, chinchillas stand out today as the only lab animals with similar enough ear structure to humans and in which otitis media can be easily produced by squirting very small amount of bacteria into the nose.