Latest Articles

Latest Articles

Listen up! Fruit Flies Key to Hearing Loss Research

Noise-Induced Hearing Loss is largely responsible for irreversible hearing damage. NIHL can be caused by a one-time exposure to a loud sound or continued exposure to high-decibel noises. Researchers at the University of Iowa are now turning to the common fruit fly to study and combat NIHL in humans. The fruit fly is the ideal animal model because the molecular structure of its ear is more similar to humans than that of rats or guinea pigs, meaning tests on fruit flies yield more accurate results.

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The Naked Truth: The Naked Mole Rat and the Elusive Cure for Cancer

The naked mole rat has a very long life span, with some living as long as 32 years, but what makes it unique is its apparent resistance to developing cancer. A team at the University of Rochester first described a process of tumor blockade called early contact inhibition that is present in the naked mole rat but not in any other mammalian species. This process might be part of this rat’s unique tumor busting superpower, effectively protecting it from the rapid cell growth and division that occurs with cancer.

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Taking a Bite Out of Parkinson’s: Snail venom helps fight brain disease

Researchers at the University of Utah tested many toxins in the omaria cone snail’s venom and found that Om1A is unique because it fits tightly into some receptors but not others. This desirable attribute is beneficial because if a drug can be developed to mimic the shape of the toxin, it will be less likely to bind with the wrong receptor and cause unwanted side effects. This slow but steady work will someday hopefully transform the omaria cone snail’s debilitating bite into medicine that gives mobility back to people with Parkinson’s disease.

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Kitties & Kids: Fighting a Fatal Genetic Disease

Now that Siamese cats are available as genetic models for Niemann-Pick disease, in-depth studies on the biochemical properties of the disease are being performed. Previously, studies on Niemann-Pick disease were performed on rodents with drug-induced enzyme deficiencies, which was less than ideal. Although there are obstacles to be faced, researchers are optimistic that Siamese cats will speed the search for a cure or effective treatments for Niemann-Pick disease.

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Let’s Get Together: Fish Hybrids and Melanoma

Using swordtail-platyfish hybrids, scientists found a proto-oncogene – a normal gene that causes cancer when turned on – that causes spontaneous melanoma formation in these fish. This gene, XMRK, resides on the sex chromosome and allows melanoma to be inherited. The importance of studying XMRK in swordtail-platyfish models is the universal commonalities among proto-oncogenes in different organisms, meaning a similar gene with similar inheritance patterns could very well be what causes melanoma in humans.

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What Cows Can Teach Us About Autism

A team at Yale University analyzed the effects of a new oxytocin nasal spray on social functioning of autistic children. They reported that the medication facilitated social functioning. Other experiments using animal models have shown that the medication promotes social behavior and bonding. With a little help from a few run-of-the-mill dairy cows, the role of oxytocin in social behaviors and anxiety is now paving the way towards new treatments for autism.

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Lost: How Bats are Helping People Find Their Way Home

Patients with Developmental Topographic Disorientation wake up every day only to face a strange, seemingly new world. Tasks that many of us do without even thinking are constant battles. In order to update the model for spatial navigation, scientists are beginning to study the brains of bats which are best known for their ability to navigate using a series of sound waves, also known as echolocation. These new studies using bats shine a ray of hope for those with this condition.

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Dogs Really Are Man’s Best Friend: Osteosarcoma Research in Great Danes

Great Danes are one of the best canine models for human cancer research because they have the highest chance of developing a malignancy in their lifetime. Compared to lab rats and mice, Great Danes are better models for human disease because they are genetically more similar. All too often, treatments that have worked in lab mice haven't worked when we've taken them to human clinical trials. [The canine] model is much closer to human disease.

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Hope is Hopping Toward Us: Fox Squirrels and the Answer to Gunther’s Disease

Fox squirrels are a relatively new animal model in finding a cure for Gunther’s disease. Already, findings have led to experimental bone marrow transplants which were successful in a few cases. Additionally, blood transfusions to suppress heme production as well as spleen removal have helped some patients. Realistically, a cure for Gunther’s disease is still many years off. For now, patients can hope that the fox squirrel will soon share its secret for beating the symptoms of Gunther’s disease.

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